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Used mainly as a fourth-line therapy for MM, Darzalex is also being increasingly used in combination therapies with Pomalyst.
This has helped to increase the use of Pomalyst as a second- and third-line MM therapy.
Patients received a median of 2 (range 1-4) prior lines of therapy; 60% were lenalidomide refractory.
The most common grade 3/4 treatment-emergent adverse events were thrombocytopenia (31%), lymphopenia (24%), anemia (21%), and neutropenia (21%).
This phase 1b study evaluated daratumumab plus carfilzomib and dexamethasone (DKd) in patients with RRMM after 1-3 prior lines of therapy, including bortezomib and an immunomodulatory drug; lenalidomide-refractory patients were eligible.
Carfilzomib- and daratumumab-naïve patients (N = 85) received carfilzomib weekly on Days 1, 8, and 15 of each 28-day cycle (20 mg/m thereafter), and dexamethasone 40 mg/week.
This type of cancer usually gets worse quickly if it is not treated.”Additionally, in partnership with Bluebird Bio, Celgene has initiated human testing for the innovative multiple myeloma therapy BB-2121.
CELG) has been working on its immunomodulatory backbone drugs Revlimid and Pomalyst to develop combination therapies that can be used for treating all lines of MM (multiple myeloma).
One of the reasons is that it can take decades for cancer to develop after a dangerous exposure.
Agent Orange was used extensively by the United States military during the Vietnam War to clear vegetation to make it easier to see enemy soldiers.
Infusion-related reactions were observed in 60% and 43% of single- and split-first dose patients, respectively.
Overall response rate was 84% (79% in lenalidomide-refractory patients).